Osteoporosis patients may soon be able uhrobyty daily injection pens for implanted microchip that releases the drug by pressing remote control button. clinical trial in a group of seven women with osteoporosis in protest of Denmark is the first wireless controlled microchips that can release drugs in the body at any time. women were 19 and 20 doses in court, but scientists have discussed plans to develop the chip, which provides 365 days is "medicine. microchip drug release on command from an external device wireless. This control system receives the medication into the bloodstream faster, similar injections. "Doctors will be able to adjust treatment of their patients via computer or mobile phone," said Robert Farra, president and CEO of microchips Inc, a company that for the device. Farra is a co-author, along with colleagues from MIT, Harvard Medical School, OnDemand Therapy Inc, and Case Western Reserve University. The authors believe that the microchip can be a better alternative for long-term use of daily injections filled pens. Patients with severe osteoporosis often have to give yourself daily injections of drugs that require refrigeration. Along with the psychological burden of daily injections, the elderly may be arthritis or other health problems that make the injection physically difficult.
Since osteoporosis is a "silent" diseaseaffected people do not feel better or worse, as their bone density decreasesmany patients simply stop taking medication to avoid the hassles of daily injections. Implant can help circumvent the high landing on compliance with the patient, Farra said. about the size of the pacemaker, device includes daily dose into the tiny holes that appear open or pre-programmed schedule or wireless signal. "Drugs are in different wells," says Robert Langer, professor of chemical and biomedical engineering at MIT. "Each of these wells covered with nano-thin layer of gold, which protects the drug for years, if necessary, and does not prevent him from being released. "Send wireless signal and leads to gold dissolved, releasing medication into the bloodstream. In order to adapt Microchip Technology for human use, the team first had to come up with a way to seal each bag to be sealed at room temperature. They developed a special welding process of compression designed to provide long-term seal. Researchers have also developed a gold layer that is strong enough to protect the contents of each tank, but very thin to dissolve the team. Researchers are developing chips with wells to maintain milligram dose of medication, because most drugs that can be delivered to the device will need a small dose, potent drugs. Despite the ability of the microchip to deliver drugs in the laboratory, fibrous collagen-based membrane usually develop around the device once it has been implanted in animals. Researchers were concerned that fibrous tissue can potentially slow the absorption of the drug. Researchers implanted microchip just below the waist in seven women aged 65 to 70 years. Tracing women over 12 months, the team showed that the implant is delivered osteoporosis drug teriparatide (Forteo) as lasix drug dose effectively as daily injections. fibrous membranes made an appearance around the device, but it does not interfere with drug delivery and was "pretty thin, so read the label through a microchip," Farra said. Treatment improved bone formation and reduces the risk of fractures, as evidenced by the presence of signaling biochemical markers of bone formation, bone mass and bone resorption. " And much less deviation from dose to dose than injections, "Long said," so it's safer and more effective in this regard. "
Farra said that the cost of devices, drugs, and implementation procedures are, the osteoporosis drug would be compared with the price of an annual value of the injection Forteo. The company hopes to make the device available for the primary treatment of osteoporosis for five years. At the same time, they see many other uses for this device, including using it to deliver multiple drugs simultaneously, and weaning the patient off certain medications, releasing various concentrations of the drug for. time, or even replace life vaccination injections from one chip research appeared in Science Translational Medicine Released. February 16, 2012
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